5 Simple Techniques For https://www.ceesdekker.net

5 Simple Techniques For https://www.ceesdekker.net

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Using one-molecule optical and AFM imaging and power-spectroscopy methods, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests include:

Human Rad51 filaments on double- and one-stranded DNA: correlating regular and irregular kinds with recombination functionality.

The next content are merged in Scholar. Their combined citations are counted only for the very first write-up.

Non-equilibrium folding of person DNA molecules recaptured as much as 1000 occasions inside a strong state nanopore

2012, discovery that nucleoid occlusion underlies the precision of bacterial cell division; and initially ever analyze with the dynamics DNA supercoils and the discovery of supercoil hopping

The coiled-coil of your human Rad50 DNA repair service protein includes specific segments of enhanced versatility

Length Charge of unique carbon nanotubes by nanostructuring While using the scanning tunneling microscope

Studying DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.

‘You should not just consider the concerns of tomorrow, but additionally think about the queries in the day right after tomorrow’

At the moment, we also realized that it should be possible to use a single semiconducting carbon nanotube to make a transistor — and we established out to really make it. We stretched specific semiconducting nanotubes across metallic electrodes and employed the underlying silicon substrate as a gate electrode, establishing the basic a few-terminal format of a field-outcome transistor (Fig.

‘The idea that There exists such a matter to be https://www.ceesdekker.net a beginning, an enormous bang, is currently an interesting signpost to take into consideration that there was a creator. But extra generally, and on the basis of pure rationality, I also get there in a Christian interpretation of reality. An atheistic worldview is really a naturalistic worldview: fundamentally, you'll find only atoms and normal forces that we can easily evaluate.

‘That fears the synthetic mobile, as part of the Dutch BaSyC initiative. Craig Venter seemed major-down in Individuals times and identified about five hundred genes that happen to be minimally needed for the performing cell. We want to glance bottom-up: how do we go from the few molecules to a whole Organic system?

2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of very long-variety conformational improvements in Mre11/DNA restore complexes; and initially force measurements over a DNA molecule inside of a nanopore

It had been a very exciting time, all through which I obtained many support from Delft University of Know-how, where I was a professor at time, And that i begun a number of collaborations with molecular biologists. That assisted me study lots.’